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CS-W001157 4
Total: USD 88.00

10H-Phenothiazine, 10-methyl-

  • CAS No. 1207-72-3

  • Cat. No. CS-0031416
  • Purity≥98%
  • MDL No.MFCD00041836

*For research and further manufacturing use only, not for direct human use.

10H-Phenothiazine, 10-methyl-|CS-0031416

Structure of 1207-72-3

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General Information

  • CAS No. 1207-72-3
  • Cat. No. CS-0031416
  • Purity ≥98%
  • MDL No. MFCD00041836
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₁NS
  • Molecular Weight 213.30
  • Synonym(s) NSC 120; Phenothiazine, 10-methyl-
  • SMILES CN1C2=C(SC3=CC=CC=C13)C=CC=C2

Description

10-Methylphenothiazine is a bench-stable, electron-rich heterocycle featuring a methyl-substituted phenothiazine core. This compound serves as a key scaffold in organic synthesis, enabling efficient access to functionalized derivatives through selective oxidation or metal-catalyzed coupling. Its robust stability under standard conditions supports reliable use in process development workflows.

Application

10-Methylphenothiazine serves as a versatile heterocyclic building block in medicinal chemistry, offering enhanced electron-donating character due to the methyl substitution at the 10-position. It functions as a core scaffold in the synthesis of bioactive molecules, particularly in antipsychotic and antimicrobial agents. The compound exhibits good bench stability and facilitates palladium-catalyzed cross-coupling reactions, enabling efficient construction of complex molecular architectures with high functional group tolerance.

Synthesis

  • Route1
    • In-stock
      Phenothiazine|CS-0008338
      92-84-2
    • null|null
      74-88-4
    • ~99%
    • In-stock
      10H-Phenothiazine, 10-methyl-|CS-0031416
      1207-72-3

    References

    • Kim, Young Chul; Lee, Sun-Hee; Kim, Man Su; Cha, Yong-Bum; Ahn, Kwang-Hyun Molecular Crystals and Liquid Crystals, 2010 , vol. 520, p. 36 - 43
  • Route2
    • In-stock
      Phenothiazine|CS-0008338
      92-84-2
    • null|null
      616-38-6
    • ~72%
    • In-stock
      10H-Phenothiazine, 10-methyl-|CS-0031416
      1207-72-3

    References

    • Zhao, Sheng-Yin; Zhang, Hai-Quan; Zhang, Deng-Qing; Shao, Zhi-Yu Synthetic Communications, 2012 , vol. 42, # 1 p. 128 - 135
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 75, p. 5422,5425 Journal of the Chemical Society, , p. 1834

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   3.9191
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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