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CS-W001157 4
Total: USD 88.00

6-Bromo-1H-indazol-5-ol

  • CAS No. 1206800-18-1

  • Cat. No. CS-W000386
  • Molecule weight213.03
  • Purity≥95%
  • MDL No.MFCD16877652

*For research and further manufacturing use only, not for direct human use.

6-Bromo-1H-indazol-5-ol|CS-W000386

Structure of 1206800-18-1

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General Information

  • CAS No. 1206800-18-1
  • Cat. No. CS-W000386
  • Purity ≥95%
  • MDL No. MFCD16877652
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrN₂O
  • Molecular Weight 213.03
  • Synonym(s) 5-HYDROXY-6-BROMO-1H-INDAZOLE
  • SMILES Brc1cc2[nH]ncc2cc1O

Description

6-Bromo-1H-indazol-5-ol features a brominated indazol scaffold with a phenolic hydroxyl group at the 5-position, enabling direct functionalization in cross-coupling and derivatization workflows. The electron-deficient core supports efficient palladium-catalyzed transformations, while the hydroxyl moiety offers sites for esterification or metal coordination. This bench-stable compound serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and bioactive heterocycles.

Application

6-Bromo-1H-indazol-5-ol serves as a versatile building block for the synthesis of biologically active heterocycles, enabling palladium-catalyzed cross-coupling reactions at the bromo position. The phenolic hydroxyl group provides a handle for derivatization and enhances solubility, while the indazolone scaffold offers stability under standard reaction conditions. This compound facilitates efficient access to diversified scaffolds in medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.91
  • LogP   2.031
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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