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CS-W001157 4
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6-Bromo-4-chloropyridin-2-amine

  • CAS No. 1206249-65-1

  • Cat. No. CS-0130963
  • Purity≥95%
  • MDL No.MFCD14582019

*For research and further manufacturing use only, not for direct human use.

6-Bromo-4-chloropyridin-2-amine|CS-0130963

Structure of 1206249-65-1

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General Information

  • CAS No. 1206249-65-1
  • Cat. No. CS-0130963
  • Purity ≥95%
  • MDL No. MFCD14582019
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BrClN₂
  • Molecular Weight 207.46
  • Synonym(s) 6-Bromo-4-chloro-pyridin-2-ylamine
  • SMILES NC1=NC(Br)=CC(Cl)=C1

Description

6-Bromo-4-chloropyridin-2-amine features a pyridine core functionalized with bromo and chloro substituents at the 6- and 4-positions, respectively, and an amino group at the 2-position. This electron-deficient heterocycle serves as a key building block in medicinal chemistry for constructing kinase inhibitors and bioactive scaffolds. The molecule exhibits enhanced reactivity in palladium-catalyzed cross-coupling reactions due to the orthogonal halogenation pattern, enabling selective functionalization. Its bench-stable nature facilitates handling under standard conditions.

Application

6-Bromo-4-chloropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo and chloro substituents offer orthogonal functionalization potential, facilitating sequential derivatization. Its stability under standard reaction conditions and compatibility with diverse coupling partners make it ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.0797
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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