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CS-W001157 4
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Cbz-NH-PEG1-CH2CH2COOH

  • CAS No. 1205751-19-4

  • Cat. No. CS-0116295
  • Purity≥98%
  • MDL No.MFCD14582436

*For research and further manufacturing use only, not for direct human use.

Cbz-NH-PEG1-CH2CH2COOH|CS-0116295

Structure of 1205751-19-4

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General Information

  • CAS No. 1205751-19-4
  • Cat. No. CS-0116295
  • Purity ≥98%
  • MDL No. MFCD14582436
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₇NO₅
  • Molecular Weight 267.28
  • Synonym(s) None
  • SMILES O=C(O)CCOCCNC(OCC1=CC=CC=C1)=O

Description

Cbz-NH-PEG1-CH2CH2COOH delivers a hydrophilic, bench-stable linker with a Cbz-protected amine and terminal carboxylic acid. This bifunctional reagent enables efficient conjugation in peptide synthesis and bioconjugation workflows, combining solubility and ease of handling. The PEG spacer enhances flexibility and reduces steric interference during coupling reactions.

Application

Cbz-NH-PEG1-CH₂CH₂COOH serves as a versatile bifunctional linker for peptide and protein conjugation, combining the stability of Cbz (carbobenzyloxy) protection with the solubility and flexibility of a single-ethylene glycol unit. The terminal carboxylic acid enables direct amide coupling to primary amines, while the PEG spacer enhances solubility and reduces aggregation in biological applications. Ideal for solid-phase synthesis and bioconjugate development, it offers reliable bench stability and straightforward purification via standard chromatographic methods.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   1.4041
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   8

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