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CS-W001157 4
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Cbz-NH-PEG8-C2-acid

  • CAS No. 1334177-87-5

  • Cat. No. CS-0105529
  • Purity≥95%
  • MDL No.MFCD11041145

*For research and further manufacturing use only, not for direct human use.

Cbz-NH-PEG8-C2-acid|CS-0105529

Structure of 1334177-87-5

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General Information

  • CAS No. 1334177-87-5
  • Cat. No. CS-0105529
  • Purity ≥95%
  • MDL No. MFCD11041145
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₄₅NO₁₂
  • Molecular Weight 575.65
  • Synonym(s) None
  • SMILES O=C(OCC1=CC=CC=C1)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

Description

Cbz-NH-PEG8-C2-acid features a carbamoyl-protected amine linked via an 8-ethylene glycol spacer to a terminal carboxylic acid. This bifunctional construct enables site-specific conjugation in bioconjugation workflows, combining the stability of the Cbz group with the solubility and flexibility of PEG8. Ideal for linker development in peptide-drug conjugates and protein engineering.

Application

Cbz-NH-PEG8-C2-acid serves as a versatile, bench-stable linker for bioconjugation and peptide synthesis, enabling efficient coupling via its terminal carboxylic acid group. The PEG8 spacer provides enhanced solubility and reduced aggregation, while the Cbz (carbobenzyloxy) protecting group ensures reliable nitrogen functionality during multistep synthesis. This reagent facilitates orthogonal functionalization in complex molecule assembly and is compatible with standard amide bond formation protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   149.47
  • LogP   1.5203
  • H_Acceptors   11
  • H_Donors   2
  • Rotatable_Bonds   29

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