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CS-W001157 4
Total: USD 88.00

2-Methyl-N-phenylaniline

  • CAS No. 1205-39-6

  • Cat. No. CS-0152949
  • Purity≥98%
  • MDL No.MFCD01318642

*For research and further manufacturing use only, not for direct human use.

2-Methyl-N-phenylaniline|CS-0152949

Structure of 1205-39-6

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General Information

  • CAS No. 1205-39-6
  • Cat. No. CS-0152949
  • Purity ≥98%
  • MDL No. MFCD01318642
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₃N
  • Molecular Weight 183.25
  • Synonym(s) Phenyl o-tolylamine
  • SMILES CC1=CC=CC=C1NC2=CC=CC=C2

Description

2-Methyl-N-phenylaniline features a methyl-substituted aniline core paired with a phenyl group on nitrogen, delivering enhanced electron density and steric profile. This structure supports robust performance in coupling reactions and facilitates use as a building block in pharmaceutical synthesis and organic materials development under standard conditions.

Application

2-Methyl-N-phenylaniline serves as a versatile arylamine building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and functionalized anilines. Its moderate electron-donating character and bench-stable nature facilitate direct electrophilic substitution and coupling reactions. The compound exhibits excellent functional group tolerance and simplifies purification due to its crystalline form, making it well-suited for medicinal chemistry campaigns and process development workflows.

Synthesis

  • Route1
    • In-stock
      2-Tolylboronic acid|CS-W001232
      16419-60-6
    • null|null
      74497-02-2
    • ~92%
    • In-stock
      2-Methyl-N-phenylaniline|CS-0152949
      1205-39-6

    References

    • Sawant, Sanghapal D.; Srinivas, Mahesuni; Aravinda Kumar; Lakshma Reddy; Singh, Parvinder Pal; Singh, Baldev; Sharma, Amit Kumar; Sharma; Vishwakarma, Ram A. Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5351 - 5354
  • Route2
    • In-stock
      1-Iodo-2-methylbenzene|CS-W007394
      615-37-2
    • null|null
      74497-02-2
    • ~93%
    • In-stock
      2-Methyl-N-phenylaniline|CS-0152949
      1205-39-6

    References

    • Tsukada, Naofumi; Ohnishi, Nozomi; Aono, Shiori; Takahashi, Fusako Organometallics, 2012 , vol. 31, # 21 p. 7336 - 7338
  • Route3
    • null|null
      95-49-8
    • null|null
      74497-02-2
    • ~98%
    • In-stock
      2-Methyl-N-phenylaniline|CS-0152949
      1205-39-6

    References

    • Huang, Pei; Wang, Yi-Xiang; Yu, Hong-Fei; Lu, Jian-Mei Organometallics, 2014 , vol. 33, # 7 p. 1587 - 1593

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   3.73862
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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