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CS-W001157 4
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3-(4-(Trifluoromethyl)phenyl)azetidine hydrochloride

  • CAS No. 1203683-75-3

  • Cat. No. CS-0203507
  • Molecule weight237.65
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(4-(Trifluoromethyl)phenyl)azetidine hydrochloride|CS-0203507

Structure of 1203683-75-3

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General Information

  • CAS No. 1203683-75-3
  • Cat. No. CS-0203507
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁ClF₃N
  • Molecular Weight 237.65
  • Synonym(s) 3-[4-(trifluoromethyl)phenyl]azetidine,hydrochloride
  • SMILES FC(F)(C1=CC=C(C2CNC2)C=C1)F.Cl

Description

This trifluoromethyl-substituted azetidine hydrochloride features a strained four-membered ring bearing an electron-deficient aryl group, enhancing metabolic stability and bioavailability. The hydrochloride salt improves solubility and crystallinity, facilitating handling in synthetic workflows.

Application

3-(4-(Trifluoromethyl)phenyl)azetidine hydrochloride serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive heterocycles via standard coupling and functionalization reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the azetidine core provides conformational rigidity and favorable pharmacokinetic properties. Bench-stable and readily purified, it functions effectively in amide bond formation, Suzuki-Miyaura coupling, and late-stage diversification workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.814
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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