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Structure of 1203683-75-3
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This trifluoromethyl-substituted azetidine hydrochloride features a strained four-membered ring bearing an electron-deficient aryl group, enhancing metabolic stability and bioavailability. The hydrochloride salt improves solubility and crystallinity, facilitating handling in synthetic workflows.
3-(4-(Trifluoromethyl)phenyl)azetidine hydrochloride serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive heterocycles via standard coupling and functionalization reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the azetidine core provides conformational rigidity and favorable pharmacokinetic properties. Bench-stable and readily purified, it functions effectively in amide bond formation, Suzuki-Miyaura coupling, and late-stage diversification workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: