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Structure of 1202993-11-0
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This pyrazole carboxylic acid features a difluoromethyl group at the 3-position and a chloro substituent at the 5-position, delivering enhanced electron-withdrawing character and metabolic stability. The methyl group at N1 improves solubility and synthetic handle compatibility. This scaffold integrates readily into bioactive molecules for medicinal chemistry campaigns requiring lipophilic, halogenated heterocycles with balanced polarity.
5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its trifunctional architecture—combining a carboxylic acid, chloro, and difluoromethyl group—facilitates diverse downstream transformations, including amide formation, Suzuki-Miyaura coupling, and nucleophilic substitution. The molecule exhibits excellent bench stability and compatibility with common purification methods, making it ideal for iterative synthesis campaigns targeting pharmaceutical scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: