Lot numbers can be found on the outside label of a product:
1-(1-Methylpiperidin-4-yl)-1H-pyrazol-4-amine
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CAS No. 1201935-36-5
- Cat. No. CS-W006308
- Purity≥95%
- MDL No.MFCD19704303
*For research and further manufacturing use only, not for direct human use.
Structure of 1201935-36-5
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General Information
- CAS No. 1201935-36-5
- Cat. No. CS-W006308
- Purity ≥95%
- MDL No. MFCD19704303
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₆N₄
- Molecular Weight 180.25
- Synonym(s) 1-(1-methylpiperidin-4-yl)pyrazol-4-amine
- SMILES NC1=CN(C2CCN(C)CC2)N=C1
Description
This pyrazole derivative features a 1-methylpiperidin-4-yl group that enhances solubility and metabolic stability, while the terminal amine enables facile conjugation. The electron-rich pyrazole core provides strong hydrogen-bonding capacity, making it a valuable scaffold in medicinal chemistry for targeting kinase and GPCR systems under standard bench conditions.
Application
1-(1-Methylpiperidin-4-yl)-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling rapid access to diverse heterocyclic scaffolds. The pyrazole core supports robust functionalization at the 4-position, while the 1-methylpiperidine moiety provides a polar, basic amine for salt formation and solubility enhancement. This scaffold exhibits favorable bench stability and compatibility with standard coupling reactions, facilitating efficient synthesis of kinase inhibitors and other bioactive compounds through modular derivatization.
Synthesis
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Route1
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1201935-35-4 - ~79%
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In-stock
1201935-36-5
References
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ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2009/153589 A1, 2009 ; Location in patent: Page/Page column 109 ; WO 2009/153589 A1
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Route2
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In-stock
1201916-87-1 - ~%
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In-stock
1201935-36-5
References
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ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; AHMED, Feryan; WALKER, Joel R.; HUNTLEY, Raymond Patent: WO2013/109388 A2, 2013 ; Location in patent: Page/Page column 156 ;
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Route3
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109384-19-2
- ~%
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In-stock
1201935-36-5
References
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ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; AHMED, Feryan; WALKER, Joel R.; HUNTLEY, Raymond Patent: WO2013/109388 A2, 2013 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 47.08
- LogP 0.732
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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