Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

6-Chloro-3-methylpicolinic acid

  • CAS No. 1201924-32-4

  • Cat. No. CS-D0312
  • Purity≥98%
  • MDL No.MFCD16249840

*For research and further manufacturing use only, not for direct human use.

6-Chloro-3-methylpicolinic acid|CS-D0312

Structure of 1201924-32-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 1201924-32-4
  • Cat. No. CS-D0312
  • Purity ≥98%
  • MDL No. MFCD16249840
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) 6-chloro-3-methylpyridine-2-carboxylicaci
  • SMILES O=C(O)C1=NC(Cl)=CC=C1C

Description

6-Chloro-3-methylpicolinic acid features a sterically hindered pyridine core with complementary electron-withdrawing and donating substituents. This combination enhances its utility as a building block in medicinal chemistry, enabling efficient coupling reactions under mild conditions. The chloro group facilitates downstream functionalization, while the methyl moiety imparts increased lipophilicity and metabolic stability.

Application

6-Chloro-3-methylpicolinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-chloro and methyl substituents enable selective functionalization, while the carboxylic acid group facilitates coupling reactions. The compound exhibits good bench stability and is compatible with standard amide bond formation, Suzuki-Miyaura cross-coupling, and cyclization protocols used in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee Patent: WO2014/4230 A1, 2014 ; Location in patent: Page/Page column 8; 45 ;
  • Route2

    References

    • WO2009/155156 A1, ; Page/Page column 63 ; WO 2009/155156 A1
  • Route3

    References

    • WO2009/155156 A1, ; WO 2009/155156 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.74162
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 6-Chloro-3-methylpicolinic acid sigma6-Chloro-3-methylpicolinic acid manufacturer6-Chloro-3-methylpicolinic acid price6-Chloro-3-methylpicolinic acid structure6-Chloro-3-methylpicolinic acid SDSbuy 6-Chloro-3-methylpicolinic acid6-Chloro-3-methylpicolinic acid supplier6-Chloro-3-methylpicolinic acid uses6-Chloro-3-methylpicolinic acid molecular weightprice of 6-Chloro-3-methylpicolinic acid6-Chloro-3-methylpicolinic acid chemical name formula of 6-Chloro-3-methylpicolinic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label