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CS-W001157 4
Total: USD 88.00

(1-Isopropyl-1H-pyrazol-4-yl)boronic acid

  • CAS No. 1201643-90-4

  • Cat. No. CS-0088068
  • Purity≥98%
  • MDL No.MFCD16036118

*For research and further manufacturing use only, not for direct human use.

(1-Isopropyl-1H-pyrazol-4-yl)boronic acid|CS-0088068

Structure of 1201643-90-4

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General Information

  • CAS No. 1201643-90-4
  • Cat. No. CS-0088068
  • Purity ≥98%
  • MDL No. MFCD16036118
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁BN₂O₂
  • Molecular Weight 153.97
  • Synonym(s) None
  • SMILES CC(N1N=CC(B(O)O)=C1)C

Description

This pyrazolylboronic acid features a sterically hindered isopropyl group that enhances stability and solubility in polar solvents. The boronic acid moiety enables reliable Suzuki-Miyaura coupling under standard conditions, delivering efficient C–C bond formation in complex molecule synthesis.

Application

(1-Isopropyl-1H-pyrazol-4-yl)boronic acid serves as a stable, bench-friendly building block for Suzuki-Miyaura cross-coupling reactions. Its pyrazole core provides enhanced solubility and functional group tolerance, enabling efficient late-stage diversification in medicinal chemistry. The isopropyl substituent improves crystallinity and purification ease, while the boronic acid moiety facilitates reliable coupling with aryl, heteroaryl, and vinyl halides under standard conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.28
  • LogP   -0.8562
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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