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(1H-Pyrazolo[3,4-b]pyridin-5-yl)boronic acid

  • CAS No. 1417985-25-1

  • Cat. No. CS-0108796
  • Molecule weight162.94
  • Purity≥97%
  • MDL No.MFCD18250847

*For research and further manufacturing use only, not for direct human use.

(1H-Pyrazolo[3,4-b]pyridin-5-yl)boronic acid|CS-0108796

Structure of 1417985-25-1

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General Information

  • CAS No. 1417985-25-1
  • Cat. No. CS-0108796
  • Purity ≥97%
  • MDL No. MFCD18250847
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BN₃O₂
  • Molecular Weight 162.94
  • Synonym(s) None
  • SMILES OB(C1=CN=C(NN=C2)C2=C1)O

Description

This boronate moiety integrates seamlessly into Suzuki-Miyaura cross-coupling reactions, delivering functionalized heterocycles with high efficiency. The pyrazolopyridine scaffold offers enhanced stability and solubility under standard conditions, enabling robust coupling in complex molecular architectures.

Application

(1H-Pyrazolo[3,4-b]pyridin-5-yl)boronic acid serves as a versatile building block for constructing biologically relevant heterocyclic scaffolds. Its boronic acid functionality enables reliable Suzuki-Miyaura cross-coupling reactions under mild conditions, facilitating the synthesis of complex pyrazolo-pyridine derivatives. The compound exhibits good bench stability and functional group tolerance, supporting efficient purification and integration into iterative synthetic sequences common in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   82.03
  • LogP   -1.3623
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   1

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