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1-(2-Methoxyethyl)-3,5-dimethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

  • CAS No. 1200537-40-1

  • Cat. No. CS-0161963
  • Purity≥97%
  • MDL No.MFCD22572270

*For research and further manufacturing use only, not for direct human use.

1-(2-Methoxyethyl)-3,5-dimethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|CS-0161963

Structure of 1200537-40-1

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General Information

  • CAS No. 1200537-40-1
  • Cat. No. CS-0161963
  • Purity ≥97%
  • MDL No. MFCD22572270
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₅BN₂O₃
  • Molecular Weight 280.17
  • Synonym(s) None
  • SMILES CC1(C)OB(C2=C(C)N(CCOC)N=C2C)OC1(C)C

Description

This pyrazole derivative features a methoxyethyl substituent and a sterically shielded tetramethylborolane group, enabling efficient Suzuki-Miyaura coupling under standard conditions. The electron-rich core enhances reactivity while maintaining bench stability and moisture tolerance, simplifying handling in synthetic workflows.

Application

1-(2-Methoxyethyl)-3,5-dimethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a stable, bench-ready boron building block for Suzuki-Miyaura cross-coupling reactions. The tetramethylboronate group enables efficient C–C bond formation under mild conditions, while the 2-methoxyethyl and dimethyl substituents provide enhanced solubility and functional group tolerance. This pyrazole scaffold is well-suited for constructing diverse heterocyclic frameworks in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   45.51
  • LogP   1.44554
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   4

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