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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate

  • CAS No. 1198408-35-3

  • Cat. No. CS-0112822
  • Purity≥95%
  • MDL No.MFCD11111266
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate|CS-0112822

Structure of 1198408-35-3

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Description

tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate features a pyridine nitrogen positioned ortho to the piperidine tether, enabling direct functionalization. The tert-butyl carbamate group provides stability and ease of removal under mild acidic conditions. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate serves as a versatile building block for constructing pyridine-containing heterocycles in medicinal chemistry. The tert-butyl carbamate group provides excellent bench stability and ease of removal under mild acidic conditions, while the primary amine enables direct derivatization via acylation, alkylation, or coupling reactions. Its piperidine scaffold offers favorable conformational properties and functional group tolerance, facilitating integration into diverse API candidates through standard synthetic protocols.

General Information

  • CAS No. 1198408-35-3
  • Cat. No. CS-0112822
  • Purity ≥95%
  • MDL No. MFCD11111266
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₃N₃O₂
  • Molecular Weight 277.36
  • Synonym(s) None
  • SMILES O=C(N1CCC(C2=CC=C(N)N=C2)CC1)OC(C)(C)C

Computational Chemistry Data

  • TPSA   68.45
  • LogP   2.7783
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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