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CS-W001157 4
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4-Bromo-2-ethynylpyridine

  • CAS No. 1196155-22-2

  • Cat. No. CS-0441919
  • Purity≥97%
  • MDL No.MFCD13189721

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-ethynylpyridine|CS-0441919

Structure of 1196155-22-2

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General Information

  • CAS No. 1196155-22-2
  • Cat. No. CS-0441919
  • Purity ≥97%
  • MDL No. MFCD13189721
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrN
  • Molecular Weight 182.02
  • Synonym(s) None
  • SMILES C#CC1=NC=CC(=C1)Br

Description

4-Bromo-2-ethynylpyridine features a strategically positioned ethynyl group flanked by a bromine atom and a pyridine nitrogen, enabling seamless integration into copper-catalyzed coupling reactions. This electron-deficient alkyne serves as a key building block for conjugated architectures in synthetic organic chemistry and materials science applications.

Application

4-Bromo-2-ethynylpyridine serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to functionalized biaryl and heteroaryl scaffolds. The terminal alkyne moiety facilitates Sonogashira coupling under mild conditions, while the bromopyridine group supports Suzuki-Miyaura and Negishi transformations. Its bench-stable nature and compatibility with diverse functional groups make it ideal for iterative synthesis in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.8254
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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