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CS-W001157 4
Total: USD 88.00

1-Chloro-4-(methoxymethyl)benzene

  • CAS No. 1195-44-4

  • Cat. No. CS-0182615
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Chloro-4-(methoxymethyl)benzene|CS-0182615

Structure of 1195-44-4

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General Information

  • CAS No. 1195-44-4
  • Cat. No. CS-0182615
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClO
  • Molecular Weight 156.61
  • Synonym(s) 1-chloro-4-(methoxymethyl)-benzene
  • SMILES COCC1=CC=C(Cl)C=C1

Description

1-Chloro-4-(methoxymethyl)benzene features a para-substituted aryl chloride paired with a methoxymethyl side chain, enabling straightforward functionalization in cross-coupling and nucleophilic substitution reactions. The electron-withdrawing chlorine enhances reactivity while the methoxymethyl group offers a handle for further derivatization under mild conditions.

Application

1-Chloro-4-(methoxymethyl)benzene serves as a versatile aryl halide building block for Suzuki-Miyaura and Negishi coupling reactions, offering excellent stability and compatibility with diverse functional groups. The methoxymethyl substituent provides orthogonal protection for alcohols and enables selective transformations, facilitating efficient synthesis of complex aromatic scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • In-stock
      p-Chlorotoluol|CS-D1681
      873-76-7
    • null|null
      74-88-4
    • ~84%
    • In-stock
      1-Chloro-4-(methoxymethyl)benzene|CS-0182615
      1195-44-4

    References

    • XEROX CORPORATION Patent: US2008/255389 A1, 2008 ; Location in patent: Page/Page column 10 ;
  • Route2
    • null|null
      16881-77-9
    • In-stock
      4-Chlorobenzaldehyde|CS-W008778
      104-88-1
    • ~90%
    • In-stock
      1-Chloro-4-(methoxymethyl)benzene|CS-0182615
      1195-44-4

    References

    • Argouarch, Gilles; Grelaud, Guillaume; Roisnel, Thierry; Humphrey, Mark G.; Paul, Frederic Tetrahedron Letters, 2012 , vol. 53, # 37 p. 5015 - 5018
  • Route3
    • In-stock
      1-Bromo-4-chlorobenzene|CS-0015927
      106-39-8
    • null|null
      27490-32-0
    • ~71%
    • In-stock
      1-Chloro-4-(methoxymethyl)benzene|CS-0182615
      1195-44-4

    References

    • Kosugi, Masanori; Sumiya, Takashi; Ogata, Toshimi; Sano, Hiroshi; Migita, Toshihiko Chemistry Letters, 1984 , p. 1225 - 1226

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.4864
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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