2-Bromo-5-methylthiazole-4-carboxylic acid

Name: 2-Bromo-5-methylthiazole-4-carboxylic acid
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CAS No. 1194374-25-8
Cat. No. CS-W021622
Purity≥97%
MDL No.MFCD12404925

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Bromo-5-methylthiazole-4-carboxylic acid|CS-W021622

Structure of 1194374-25-8

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General Information

CAS No. 1194374-25-8
Cat. No. CS-W021622
Purity ≥97%
MDL No. MFCD12404925
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄BrNO₂S
Molecular Weight 222.06
Synonym(s) 2-bromo-5-methyl-1,3-thiazole-4-carboxylic acid
SMILES O=C(C1=C(C)SC(Br)=N1)O

Description

2-Bromo-5-methylthiazole-4-carboxylic acid features a brominated thiazole core with a methyl group at the 5-position and a carboxylic acid at the 4-position, enabling direct coupling in synthetic routes. This electron-deficient heterocycle integrates readily into bioactive scaffolds, offering enhanced reactivity for C–C and C–heteroatom bond formation under standard conditions.

Application

2-Bromo-5-methylthiazole-4-carboxylic acid serves as a versatile building block in heterocyclic synthesis, enabling efficient access to thiazole-based scaffolds prevalent in medicinal chemistry. Its bromine and carboxylic acid functionalities support diverse transformations, including palladium-catalyzed cross-couplings and derivatization via amide or ester formation. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns and API intermediate development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 50.19
LogP 1.91222
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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2-Bromo-5-methylthiazole-4-carboxylic acid

CAS No. 1194374-25-8

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