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CS-W001157 4
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Methyl 2-bromo-5-methylthiazole-4-carboxylate

  • CAS No. 56355-61-4

  • Cat. No. CS-0054983
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 2-bromo-5-methylthiazole-4-carboxylate|CS-0054983

Structure of 56355-61-4

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General Information

  • CAS No. 56355-61-4
  • Cat. No. CS-0054983
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO₂S
  • Molecular Weight 236.09
  • Synonym(s) methyl 2-bromo-5-methyl-1,3-thiazole-4-carboxylate
  • SMILES O=C(C1=C(C)SC(Br)=N1)OC

Description

Methyl 2-bromo-5-methylthiazole-4-carboxylate features a brominated thiazole core with dual functional handles: a methyl ester for derivatization and a bromine atom enabling cross-coupling reactions. This bench-stable, moisture-tolerant reagent integrates efficiently into synthetic sequences requiring regioselective transformations.

Application

Methyl 2-bromo-5-methylthiazole-4-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromo group. The methylthiazole core provides enhanced stability and orthogonality in multi-step sequences, while the ester functionality allows for selective derivatization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for constructing thiazole-based scaffolds in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.00062
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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