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CS-W001157 4
Total: USD 88.00

1-(2-Bromoethyl)-1H-pyrazole

  • CAS No. 119291-22-4

  • Cat. No. CS-0040580
  • Purity≥96%
  • MDL No.MFCD03727235

*For research and further manufacturing use only, not for direct human use.

1-(2-Bromoethyl)-1H-pyrazole|CS-0040580

Structure of 119291-22-4

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General Information

  • CAS No. 119291-22-4
  • Cat. No. CS-0040580
  • Purity ≥96%
  • MDL No. MFCD03727235
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇BrN₂
  • Molecular Weight 175.03
  • Synonym(s) 1-(2-BroMoethyl)pyrazole
  • SMILES BrCCN1N=CC=C1

Description

1-(2-Bromoethyl)-1H-pyrazole features a reactive bromoalkyl handle tethered to a heteroaromatic pyrazole core, enabling efficient conjugation in synthetic transformations. This bench-stable reagent integrates readily into click chemistry protocols and functionalization workflows, offering a robust platform for constructing bioactive molecules and advanced materials.

Application

1-(2-Bromoethyl)-1H-pyrazole serves as a versatile bifunctional building block, enabling efficient conjugation of pyrazole scaffolds to nucleophilic partners via its reactive bromoalkyl group. The molecule exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for modular synthesis of bioactive heterocycles, including those found in medicinal chemistry campaigns and agrochemical development.

Synthesis

  • Route1
    • In-stock
      1H-pyrazole|CS-W008829
      288-13-1
    • null|null
      106-93-4
    • ~81%
    • In-stock
      1-(2-Bromoethyl)-1H-pyrazole|CS-0040580
      119291-22-4

    References

    • Journal of the Chemical Society. Dalton Transactions, , # 21 p. 4181 - 4191
  • Route2
    • In-stock
      1H-pyrazole|CS-W008829
      288-13-1
    • null|null
      106-93-4
    • ~20%
    • In-stock
      1-(2-Bromoethyl)-1H-pyrazole|CS-0040580
      119291-22-4
    • 1-(2-Pyrazol-1-ylethyl)pyrazole|CS-0771194
      92146-02-6

    References

    • Journal of Heterocyclic Chemistry, , vol. 35, # 6 p. 1263 - 1268
  • Route3
    • In-stock
      1H-pyrazole|CS-W008829
      288-13-1
    • null|null
      106-93-4
    • ~72%
    • In-stock
      1-(2-Bromoethyl)-1H-pyrazole|CS-0040580
      119291-22-4
    • 1-(2-Pyrazol-1-ylethyl)pyrazole|CS-0771194
      92146-02-6
    • 1-Vinyl-1H-pyrazole|CS-0951330
      20173-98-2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 7, # 3 p. 517 - 527

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   1.278
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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