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2-(3-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 1192025-01-6

  • Cat. No. CS-0097286
  • Purity≥97%
  • MDL No.MFCD12405368

*For research and further manufacturing use only, not for direct human use.

2-(3-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0097286

Structure of 1192025-01-6

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General Information

  • CAS No. 1192025-01-6
  • Cat. No. CS-0097286
  • Purity ≥97%
  • MDL No. MFCD12405368
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅BClFO₂
  • Molecular Weight 256.51
  • Synonym(s) None
  • SMILES CC1(C)C(C)(C)OB(C2=CC=CC(Cl)=C2F)O1

Description

This boronate ester features a 3-chloro-2-fluorophenyl group attached to a tetramethyl-1,3,2-dioxaborolane scaffold, delivering enhanced stability and reactivity in cross-coupling applications. The electron-deficient aryl moiety enables efficient palladium-catalyzed coupling under standard conditions. Bench-stable and moisture-tolerant, it streamlines synthesis of functionalized biaryl architectures.

Application

2-(3-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boron building block for Suzuki-Miyaura cross-coupling reactions. Its ortho-heteroaryl substitution enables efficient construction of biaryl scaffolds with retained halogen functionality for downstream functionalization. The tetramethyl-substituted dioxaborolane core ensures excellent shelf stability and compatibility with diverse reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.7783
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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