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CS-W001157 4
Total: USD 88.00

Methyl 6-(methylsulfonyl)nicotinate

  • CAS No. 1190948-26-5

  • Cat. No. CS-0469949
  • Molecule weight215.23
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 6-(methylsulfonyl)nicotinate|CS-0469949

Structure of 1190948-26-5

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General Information

  • CAS No. 1190948-26-5
  • Cat. No. CS-0469949
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₄S
  • Molecular Weight 215.23
  • Synonym(s) None
  • SMILES COC(=O)C1=CC=C(N=C1)S(C)(=O)=O

Description

Methyl 6-(methylsulfonyl)nicotinate features a methylsulfonyl group at the pyridine ring's 6-position, enhancing solubility and metabolic stability. This electron-withdrawing substituent imparts unique reactivity in cross-coupling and functionalization processes. The ester handle enables straightforward derivatization, while the bench-stable structure supports reliable use in synthetic workflows.

Application

Methyl 6-(methylsulfonyl)nicotinate serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine derivatives. The methylsulfonyl group provides enhanced solubility and metabolic stability, while the ester functionality permits straightforward hydrolysis or coupling reactions. This compound exhibits excellent bench stability and compatibility with standard synthetic transformations, facilitating its use in the construction of heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   73.33
  • LogP   0.2717
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

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