1-(Tetrahydro-2H-pyran-4-yl)-1h-pyrazol-4-amine

Name: 1-(Tetrahydro-2H-pyran-4-yl)-1h-pyrazol-4-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1190380-49-4
Cat. No. CS-0054472
Purity≥95%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(Tetrahydro-2H-pyran-4-yl)-1h-pyrazol-4-amine|CS-0054472

Structure of 1190380-49-4

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1190380-49-4
Cat. No. CS-0054472
Purity ≥95%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₃N₃O
Molecular Weight 167.21
Synonym(s) 1-Tetrahydropyran-4-yl-1H-pyrazol-4-ylamine
SMILES NC1=CN(C2CCOCC2)N=C1

Description

1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine features a pyrazole core functionalized with a tetrahydropyranyl protecting group, enabling stable storage and selective deprotection under mild acidic conditions. This bench-stable derivative integrates readily into medicinal chemistry workflows, offering a versatile scaffold for constructing bioactive heterocycles.

Application

1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized heterocyclic scaffolds. The pyrazole nitrogen at C4 provides a robust site for further derivatization, while the tetrahydro-2H-pyran-4-yl group offers excellent bench stability and orthogonal protection. This combination facilitates straightforward deprotection and functional group interconversions in multi-step syntheses, particularly valuable in late-stage modifications and API development workflows.

Synthesis

Route1
- 1190380-50-7
- ~96%
- In-stock
  
  1190380-49-4
References
- MEDICAL RESEARCH COUNCIL Patent: WO2009/122180 A1, 2009 ; Location in patent: Page/Page column 111-112 ; WO 2009/122180 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 53.07
LogP 0.8168
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydropyran compounds

Key Words

1190380-49-4 sigma1190380-49-4 manufacturer1190380-49-4 price1190380-49-4 structure1190380-49-4 SDSbuy 1190380-49-41190380-49-4 supplier1190380-49-4 uses1190380-49-4 molecular weightprice of 1190380-49-41190380-49-4 chemical name formula of 1190380-49-4

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1-(Tetrahydro-2H-pyran-4-yl)-1h-pyrazol-4-amine

CAS No. 1190380-49-4

Recommended Products