1-(Difluoromethyl)-1H-pyrazol-4-amine hydrochloride

Name: 1-(Difluoromethyl)-1H-pyrazol-4-amine hydrochloride
Brand: ChemScene
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CAS No. 1221726-31-3
Cat. No. CS-0112688
Molecule weight169.56
Purity≥95%
MDL No.MFCD14705743

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1-(Difluoromethyl)-1H-pyrazol-4-amine hydrochloride|CS-0112688

Structure of 1221726-31-3

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General Information

CAS No. 1221726-31-3
Cat. No. CS-0112688
Purity ≥95%
MDL No. MFCD14705743
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₆ClF₂N₃
Molecular Weight 169.56
Synonym(s) None
SMILES NC1=CN(C(F)F)N=C1.Cl

Description

1-(Difluoromethyl)-1H-pyrazol-4-amine hydrochloride features a difluoromethyl group at the 1-position and an amine functionality at the 4-position of the pyrazole ring, delivering enhanced metabolic stability and favorable pharmacokinetic properties. This bench-stable salt form improves solubility and handling in synthetic workflows.

Application

1-(Difluoromethyl)-1H-pyrazol-4-amine hydrochloride serves as a valuable building block for fluorinated heterocycles, enabling direct incorporation of the difluoromethyl group into bioactive scaffolds. The compound exhibits good bench stability and facilitates efficient coupling reactions due to its well-defined nitrogen functionality. Its hydrochloride salt form enhances solubility and purification compatibility in standard synthetic workflows, making it a practical reagent for medicinal chemistry and process development applications.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 43.84
LogP 1.2822
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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1-(Difluoromethyl)-1H-pyrazol-4-amine hydrochloride

CAS No. 1221726-31-3

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