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CS-W001157 4
Total: USD 88.00

(4-Hydroxy-3-(trifluoromethyl)phenyl)boronic acid

  • CAS No. 1187874-94-7

  • Cat. No. CS-W006877
  • Purity≥98%
  • MDL No.MFCD18384143

*For research and further manufacturing use only, not for direct human use.

(4-Hydroxy-3-(trifluoromethyl)phenyl)boronic acid|CS-W006877

Structure of 1187874-94-7

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General Information

  • CAS No. 1187874-94-7
  • Cat. No. CS-W006877
  • Purity ≥98%
  • MDL No. MFCD18384143
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BF₃O₃
  • Molecular Weight 205.93
  • Synonym(s) B-[4-hydroxy-3-(trifluoromethyl)phenyl]Boronic acid
  • SMILES FC(C1=CC(B(O)O)=CC=C1O)(F)F

Description

This boronic acid features a trifluoromethyl group para to the hydroxyl, enhancing electron deficiency and stability. The phenolic hydroxyl enables direct coupling in Suzuki-Miyaura reactions, while the boronic moiety delivers efficient cross-coupling under standard conditions.

Application

(4-Hydroxy-3-(trifluoromethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. Its stability under ambient conditions, combined with tolerance to diverse functional groups, facilitates straightforward purification and integration into complex molecular frameworks relevant to medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   0.0908
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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