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CS-W001157 4
Total: USD 88.00

6-Chloro-2-fluoro-3-iodopyridine

  • CAS No. 1187732-65-5

  • Cat. No. CS-0059186
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-fluoro-3-iodopyridine|CS-0059186

Structure of 1187732-65-5

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General Information

  • CAS No. 1187732-65-5
  • Cat. No. CS-0059186
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂ClFIN
  • Molecular Weight 257.43
  • Synonym(s) 2-fluoro-3-iodo-6 -chloropyridine
  • SMILES IC1=CC=C(Cl)N=C1F

Description

6-Chloro-2-fluoro-3-iodopyridine is a halogenated pyridine derivative featuring strategically positioned chlorine, fluorine, and iodine substituents. This electron-deficient heterocycle serves as a key building block in cross-coupling reactions, enabling efficient C–C and C–heteroatom bond formation under palladium catalysis. The iodine moiety provides a highly reactive handle for further functionalization, while the orthogonal halogens allow for selective transformations. Its bench-stable nature facilitates handling in synthetic workflows.

Application

6-Chloro-2-fluoro-3-iodopyridine serves as a versatile trifunctional building block in cross-coupling and heterocyclic synthesis. The orthogonal reactivity of chlorine, fluorine, and iodine enables sequential functionalization under palladium-catalyzed conditions. Its bench-stable nature and compatibility with standard Suzuki, Stille, and Negishi couplings make it ideal for constructing complex pharmaceutical scaffolds and advanced materials.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.4787
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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