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CS-W001157 4
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5-Bromo-1-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

  • CAS No. 1187421-56-2

  • Cat. No. CS-0151096
  • Molecule weight213.07
  • Purity≥98%
  • MDL No.MFCD22394541

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine|CS-0151096

Structure of 1187421-56-2

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General Information

  • CAS No. 1187421-56-2
  • Cat. No. CS-0151096
  • Purity ≥98%
  • MDL No. MFCD22394541
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉BrN₂
  • Molecular Weight 213.07
  • Synonym(s) 5-Bromo-2,3-dihydro-1-methylpyrrolo[2,3-b]pyridine
  • SMILES CN1CCC2=CC(=CN=C21)Br

Description

5-Bromo-1-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine is a heterocyclic building block featuring a brominated pyrrolopyridine core with a methyl group at the nitrogen. This scaffold offers enhanced stability and facilitates direct functionalization in cross-coupling reactions. The electron-deficient ring system enables efficient integration into pharmaceutical intermediates and advanced synthetic targets.

Application

5-Bromo-1-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo group and electron-rich heterocyclic core. The methyl substituent enhances solubility and modulates reactivity, while the dihydro-pyrrolopyridine scaffold provides a rigid framework for target-directed synthesis. Its bench stability and compatibility with standard reaction conditions facilitate efficient incorporation into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   16.13
  • LogP   1.8364
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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