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CS-W001157 4
Total: USD 88.00

5-Bromo-4-chloro-2-fluoropyridine

  • CAS No. 1184920-15-7

  • Cat. No. CS-0187119
  • Purity≥97%
  • MDL No.MFCD12911587

*For research and further manufacturing use only, not for direct human use.

5-Bromo-4-chloro-2-fluoropyridine|CS-0187119

Structure of 1184920-15-7

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General Information

  • CAS No. 1184920-15-7
  • Cat. No. CS-0187119
  • Purity ≥97%
  • MDL No. MFCD12911587
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrClFN
  • Molecular Weight None
  • Synonym(s) 4-chloro-2-fluoro-5-broMopyridine
  • SMILES C1=C(C(=CN=C1F)Br)Cl

Description

5-Bromo-4-chloro-2-fluoropyridine is a halogenated pyridine derivative featuring strategically positioned bromo, chloro, and fluoro substituents. This electron-deficient heterocycle enables direct functionalization in cross-coupling reactions and serves as a key intermediate in medicinal chemistry. The molecule exhibits enhanced reactivity due to orthogonal halogen patterns, facilitating selective transformations under mild conditions.

Application

5-Bromo-4-chloro-2-fluoropyridine serves as a versatile trifunctional pyridine building block, enabling sequential cross-coupling reactions in medicinal chemistry and materials science. Its orthogonal halogen reactivity facilitates palladium-catalyzed transformations—bromine typically reacts first, followed by chlorine and fluorine—allowing precise diversification of complex heterocyclic scaffolds with high regiocontrol and excellent functional group tolerance.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.6366
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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