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CS-W001157 4
Total: USD 88.00

2-Chloro-3-fluoro-4-hydroxypyridine

  • CAS No. 1184172-46-0

  • Cat. No. CS-0155598
  • Purity≥98%
  • MDL No.MFCD13189885
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-fluoro-4-hydroxypyridine|CS-0155598

Structure of 1184172-46-0

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Description

2-Chloro-3-fluoro-4-hydroxypyridine features a strategically positioned hydroxyl group flanked by chlorine and fluorine substituents, enabling direct functionalization in heterocyclic synthesis. This electron-deficient pyridine scaffold integrates readily into bioactive molecules, offering enhanced reactivity for C–H activation and cross-coupling processes under mild conditions.

Application

2-Chloro-3-fluoro-4-hydroxypyridine serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the pyridine ring due to orthogonal reactivity of its chloro and fluoro substituents. The hydroxyl group provides a handle for derivatization or metal-catalyzed coupling reactions. Its bench-stable nature and compatibility with palladium-mediated cross-coupling protocols make it a practical choice for constructing complex pharmaceutical scaffolds and bioactive heterocycles.

General Information

  • CAS No. 1184172-46-0
  • Cat. No. CS-0155598
  • Purity ≥98%
  • MDL No. MFCD13189885
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClFNO
  • Molecular Weight 147.53
  • Synonym(s) 2-Chloro-3-fluoropyridin-4-ol
  • SMILES C1=CN=C(C(=C1O)F)Cl

Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.5797
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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