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3-(Chloromethyl)-2-methoxypyridine hydrochloride

  • CAS No. 117934-34-6

  • Cat. No. CS-0329418
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Chloromethyl)-2-methoxypyridine hydrochloride|CS-0329418

Structure of 117934-34-6

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General Information

  • CAS No. 117934-34-6
  • Cat. No. CS-0329418
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉Cl₂NO
  • Molecular Weight 194.06
  • Synonym(s) 3-(chloromethyl)-2-methoxypyridine,hydrochloride
  • SMILES COC1=C(C=CC=N1)CCl.Cl

Description

3-(Chloromethyl)-2-methoxypyridine hydrochloride features a reactive chloromethyl group flanked by a methoxy-substituted pyridine ring, enabling efficient functionalization in medicinal chemistry. This bench-stable, moisture-tolerant reagent integrates readily into late-stage derivatization workflows, delivering direct access to biologically relevant heterocyclic scaffolds under standard conditions.

Application

3-(Chloromethyl)-2-methoxypyridine hydrochloride serves as a versatile electrophilic building block in medicinal chemistry, enabling efficient installation of pyridylmethyl linkages via nucleophilic substitution. The chloromethyl group exhibits high reactivity toward amines, thiols, and other soft nucleophiles under mild conditions, while the methoxy substituent provides moderate electron-donating character and enhances solubility. Bench-stable and readily purified by recrystallization, it functions effectively in the synthesis of heterocyclic scaffolds and targeted bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H290-H314
Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.2508
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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