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CS-W001157 4
Total: USD 88.00

3-Morpholinopyrazin-2-amine

  • CAS No. 117719-16-1

  • Cat. No. CS-0018854
  • Molecule weight180.21
  • Purity≥98%
  • MDL No.MFCD08460067

*For research and further manufacturing use only, not for direct human use.

3-Morpholinopyrazin-2-amine|CS-0018854

Structure of 117719-16-1

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General Information

  • CAS No. 117719-16-1
  • Cat. No. CS-0018854
  • Purity ≥98%
  • MDL No. MFCD08460067
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂N₄O
  • Molecular Weight 180.21
  • Synonym(s) 3-(4-Morpholinyl)-2-pyrazinamine; 3-Morpholinopyrazin-2-amine; 2-Amino-3-morpholin-4-ylpyrazine
  • SMILES NC1=NC=CN=C1N2CCOCC2

Description

3-Morpholinopyrazin-2-amine is a nitrogen-rich heterocyclic scaffold featuring a morpholine ring fused to a pyrazine core. This configuration imparts enhanced solubility and metabolic stability, making it a valuable building block in the design of kinase inhibitors and other bioactive small molecules.

Application

3-Morpholinopyrazin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrazine-based heterocycles common in kinase inhibitors and bioactive scaffolds. Its morpholine moiety enhances solubility and modulates pharmacokinetic properties, while the pyrazin-2-amine core facilitates robust coupling reactions and metal-catalyzed transformations. Bench-stable and compatible with standard purification methods, it functions effectively in multistep synthesis workflows.

Synthesis

  • Route1
    • null|null
      110-91-8
    • In-stock
      3-Chloro-2-pyrazinamine|CS-W007499
      6863-73-6
    • ~82%
    • In-stock
      3-Morpholinopyrazin-2-amine|CS-0018854
      117719-16-1

    References

    • WO2011/110545 A1, ; Page/Page column 72 ; WO 2011/110545 A1
  • Route2
    • null|null
      1400820-46-3
    • ~59%
    • In-stock
      3-Morpholinopyrazin-2-amine|CS-0018854
      117719-16-1

    References

    • Tetrahedron Letters, , vol. 53, # 40 p. 5380 - 5384

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.27
  • LogP   -0.1046
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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