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CS-W001157 4
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3-Chloro-2-pyrazinamine

  • CAS No. 6863-73-6

  • Cat. No. CS-W007499
  • Purity≥96%
  • MDL No.MFCD04114305

*For research and further manufacturing use only, not for direct human use.

3-Chloro-2-pyrazinamine|CS-W007499

Structure of 6863-73-6

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General Information

  • CAS No. 6863-73-6
  • Cat. No. CS-W007499
  • Purity ≥96%
  • MDL No. MFCD04114305
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄ClN₃
  • Molecular Weight 129.55
  • Synonym(s) 2-Amino-3-chloropyrazine
  • SMILES ClC(N=CC=N1)=C1N

Description

3-Chloro-2-pyrazinamine features a chlorinated pyrazine core with a primary amine at the adjacent position, enabling direct incorporation into heterocyclic scaffolds. This bench-stable derivative supports efficient functionalization in medicinal chemistry and materials synthesis.

Application

3-Chloro-2-pyrazinamine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrazine-based heterocycles common in kinase inhibitors and antimicrobial agents. Its dual functionality—reactive amine and electrophilic chloro group—facilitates sequential derivatization via nucleophilic substitution or coupling reactions. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for API development and scaffold diversification.

Synthesis

  • Route1

    References

    • US2012/59162 A1, ; Page/Page column 38-39 ;
  • Route2
    • In-stock
      2,3-Dichloropyrazine|CS-W016328
      4858-85-9
    • null|null
      7664-41-7
    • ~91%
    • In-stock
      3-Chloro-2-pyrazinamine|CS-W007499
      6863-73-6

    References

    • WO2004/41826 A1, ; Page 25-26 ;
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 69, p. 1034,1035 Journal of the American Chemical Society, , vol. 78, p. 242

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.7122
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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