tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate

Name: tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate
Brand: ChemScene
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CAS No. 1174020-43-9
Cat. No. CS-0048568
Molecule weight219.25
Purity≥95%
MDL No.None

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tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate|CS-0048568

Structure of 1174020-43-9

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General Information

CAS No. 1174020-43-9
Cat. No. CS-0048568
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈FNO₃
Molecular Weight 219.25
Synonym(s) trans-tert-butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate
SMILES CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H](F)C1

Description

tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate is a stereochemically defined piperidine derivative featuring a fluorine atom at the 3-position and a hydroxyl group at the 4-position. This configuration enhances metabolic stability while maintaining favorable conformational bias for targeted applications in medicinal chemistry. The tert-butyl carbamate handle enables straightforward deprotection under mild acidic conditions.

Application

tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate serves as a stereochemically defined building block for fluorinated piperidine scaffolds prevalent in medicinal chemistry. The protected hydroxyl group enables selective derivatization, while the C3-fluoro substituent imparts metabolic stability and modulates bioavailability. Its bench-stable nature and compatibility with standard coupling and reduction protocols facilitate efficient access to complex heterocyclic architectures in API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P264-P270-P330

Quality Control

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Computational Chemistry Data

TPSA 49.77
LogP 1.3262
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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tert-Butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate

CAS No. 1174020-43-9

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