Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID

  • CAS No. 116855-08-4

  • Cat. No. CS-W004531
  • Molecule weight163.13
  • Purity≥95%
  • MDL No.MFCD11040725

*For research and further manufacturing use only, not for direct human use.

1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID|CS-W004531

Structure of 116855-08-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 116855-08-4
  • Cat. No. CS-W004531
  • Purity ≥95%
  • MDL No. MFCD11040725
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅N₃O₂
  • Molecular Weight 163.13
  • Synonym(s) 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid
  • SMILES OC(=O)c1n[nH]c2c1cccn2

Description

1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid is a heteroaromatic scaffold featuring a fused pyrazole-pyridine core with a carboxylic acid group at the 3-position. This configuration imparts enhanced solubility and directional reactivity, enabling direct incorporation into bioactive molecules and pharmaceutical intermediates. The acidic functionality facilitates salt formation and conjugation under mild conditions.

Application

1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its rigid fused scaffold provides excellent metabolic stability and facilitates π-stacking interactions in target binding. The carboxylic acid group enables direct derivatization via amide coupling or esterification, while the pyrazolo[3,4-b]pyridine core exhibits favorable solubility and bench stability. This compound functions effectively in standard peptide coupling and transition-metal-catalyzed transformations, making it a practical choice for scaffold diversification in API development.

Synthesis

  • Route1

    References

    • Samumed, LLC; Hood, John; Kumar KC, Sunil; Wallace, David Mark Patent: US2013/296302 A1, 2013 ; Location in patent: Paragraph 0496 ;
  • Route2

    References

    • Canadian Journal of Chemistry, , vol. 66, # 3 p. 420-428
  • Route3
    • null|null
      109-09-1
    • ~%
    • In-stock
      1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID|CS-W004531
      116855-08-4

    References

    • WO2011/5759 A2, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   78.87
  • LogP   0.6561
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 116855-08-4 sigma116855-08-4 manufacturer116855-08-4 price116855-08-4 structure116855-08-4 SDSbuy 116855-08-4116855-08-4 supplier116855-08-4 uses116855-08-4 molecular weightprice of 116855-08-4116855-08-4 chemical name formula of 116855-08-4
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label