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Structure of 116757-66-5
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7-Methoxy-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde features a rigid, electron-rich heterocyclic core with a pendant aldehyde group. This bench-stable scaffold integrates readily into synthetic sequences requiring orthogonal reactivity and offers enhanced solubility in polar solvents. The methoxy substituent stabilizes adjacent electronic environments, enabling selective functionalization at the carbonyl site.
7-Methoxy-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocyclic scaffolds. Its aldehyde functionality facilitates standard transformations such as reductive amination, Wittig reactions, and nucleophilic additions, while the methoxy and dioxane moieties provide metabolic stability and favorable solubility. Bench-stable and compatible with common purification methods, it functions effectively in multi-step syntheses targeting CNS-active compounds and kinase inhibitors.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: