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CS-W001157 4
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1-((tert-Butyldimethylsilyl)oxy)propan-2-ol

  • CAS No. 116286-81-8

  • Cat. No. CS-0380575
  • Purity≥97%
  • MDL No.MFCD09261235

*For research and further manufacturing use only, not for direct human use.

1-((tert-Butyldimethylsilyl)oxy)propan-2-ol|CS-0380575

Structure of 116286-81-8

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General Information

  • CAS No. 116286-81-8
  • Cat. No. CS-0380575
  • Purity ≥97%
  • MDL No. MFCD09261235
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₂₂O₂Si
  • Molecular Weight 190.36
  • Synonym(s) 1-[(tert-Butyldimethylsilanyl)oxy]propan-2-ol
  • SMILES CC(O)CO[Si](C)(C(C)(C)C)C

Description

This silyl ether derivative features a tert-butyldimethylsilyl-protected hydroxyl group, offering robust stability and selective protection under standard conditions. The propan-2-ol backbone provides a well-defined scaffold for orthogonal functionalization in complex molecule synthesis.

Application

1-((tert-Butyldimethylsilyl)oxy)propan-2-ol serves as a stable, bench-ready silyl protecting group for primary and secondary alcohols, enabling selective protection in complex molecule synthesis. Its robustness under various reaction conditions and ease of removal with fluoride sources facilitate efficient deprotection workflows. This reagent functions reliably in multi-step sequences involving sensitive functional groups.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   2.389
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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