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CS-W001157 4
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7-Boc-(7-Azaspiro[3.5]nonane)-2-methanamine

  • CAS No. 1160247-15-3

  • Cat. No. CS-0048462
  • Purity≥97%
  • MDL No.MFCD12198554

*For research and further manufacturing use only, not for direct human use.

7-Boc-(7-Azaspiro[3.5]nonane)-2-methanamine|CS-0048462

Structure of 1160247-15-3

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General Information

  • CAS No. 1160247-15-3
  • Cat. No. CS-0048462
  • Purity ≥97%
  • MDL No. MFCD12198554
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₆N₂O₂
  • Molecular Weight 254.37
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC2(CC1)CC(CN)C2

Description

tert-Butyl 2-(aminomethyl)-7-azaspiro[3.5]nonane-7-carboxylate features a spirocyclic azaspiro scaffold with a pendant aminomethyl group, offering a rigid, three-dimensional core for medicinal chemistry applications. The tert-butyl ester facilitates convenient deprotection under mild acidic conditions. This compound serves as a key intermediate in the synthesis of complex nitrogen-containing heterocycles.

Application

tert-Butyl 2-(aminomethyl)-7-azaspiro[3.5]nonane-7-carboxylate serves as a versatile spirocyclic building block for medicinal chemistry, enabling efficient access to constrained nitrogen-containing scaffolds. The protected amine and carboxylate functionalities offer orthogonal reactivity, facilitating modular derivatization via standard coupling, reductive amination, or cyclization protocols. Bench-stable and readily purified, it supports scalable synthesis of bioactive molecules with defined stereochemistry.

Synthesis

  • Route1

    References

    • US2011/319381 A1, ; Page/Page column 9 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   2.3724
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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