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Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate

  • CAS No. 1159811-32-1

  • Cat. No. CS-0188027
  • Molecule weight256.06
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate|CS-0188027

Structure of 1159811-32-1

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General Information

  • CAS No. 1159811-32-1
  • Cat. No. CS-0188027
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrN₃O₂
  • Molecular Weight 256.06
  • Synonym(s) [1,2,4]Triazolo[1,5-a]pyridine-2-carboxylic acid, 6-bromo-, methyl ester
  • SMILES O=C(C1=NN2C=C(Br)C=CC2=N1)OC

Description

Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate is a bench-stable heterocyclic ester featuring a brominated triazolopyridine core. This scaffold integrates a reactive halogen site with a polar ester group, enabling direct coupling in cross-coupling reactions and facilitating downstream derivatization in medicinal chemistry and materials synthesis.

Application

Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate serves as a versatile building block for the synthesis of triazolopyridine-based scaffolds. The bromine at the C6 position enables palladium-catalyzed cross-coupling reactions, while the ester group supports further functionalization via hydrolysis or reduction. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for medicinal chemistry campaigns targeting kinase inhibitors and other bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.49
  • LogP   1.2784
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   1

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