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Structure of 1159512-66-9
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1-(2-Fluoro-5-iodophenyl)ethan-1-one features a fluorinated aryl ring paired with a reactive ketone moiety, enabling direct functionalization in cross-coupling and derivatization workflows. The para-iodo substituent facilitates palladium-catalyzed coupling, while the ortho-fluorine enhances electronic modulation and metabolic stability. This bench-stable reagent integrates efficiently into complex molecular architectures.
1-(2-Fluoro-5-iodophenyl)ethan-1-one serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The iodine handle facilitates reliable coupling under standard conditions, while the fluorine substituent enhances metabolic stability in downstream pharmaceutical intermediates. Bench-stable and readily purified by flash chromatography, it functions reliably in iterative synthesis workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: