TLR4-IN-C34-C2-COOH

Name: TLR4-IN-C34-C2-COOH
Brand: ChemScene
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CAS No. 1159408-54-4
Cat. No. CS-0137490
Purity≥95%
MDL No.MFCD30802159

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

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General Information

CAS No. 1159408-54-4
Cat. No. CS-0137490
Purity ≥95%
MDL No. MFCD30802159
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₉H₂₉NO₁₁
Molecular Weight 447.43
Synonym(s) None
SMILES O=C(O)CCCCO[C@H]1[C@H](NC(C)=O)[C@H]([C@H]([C@@H](COC(C)=O)O1)OC(C)=O)OC(C)=O

Description

TLR4-IN-C34-C2-COOH is a potent, selective inhibitor of Toll-like receptor 4 signaling, designed for precise modulation of innate immune responses. This compound features a carboxylic acid terminus enabling conjugation and bioconjugation applications. Its structure incorporates a hydrophobic core that enhances membrane permeability and target engagement. Bench-stable under standard conditions, it facilitates robust in vitro and cellular assays.

Application

TLR4-IN-C34-C2-COOH serves as a well-characterized Toll-like receptor 4 (TLR4) antagonist scaffold, enabling selective inhibition in innate immune signaling pathways. Its carboxylic acid functionality facilitates conjugation and derivatization for probe development, while the C34-C2 backbone offers enhanced metabolic stability and solubility. Functions effectively in cellular assays to modulate inflammatory responses, making it a practical tool for immunopharmacology research and target validation studies.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 163.76
LogP -0.086
H_Acceptors 10
H_Donors 2
Rotatable_Bonds 11

Other Classifications

Life Science Carbohydrates

Life Science Nucleosides & Nucleotides Other Protective Nucleosides

Chemical Biology Nucleic Acid Chemistry Protected Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

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TLR4-IN-C34-C2-COOH

CAS No. 1159408-54-4

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