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TFA-ap-dU

  • CAS No. 115899-40-6

  • Cat. No. CS-0149679
  • Molecule weight377.27
  • Purity≥98%
  • MDL No.MFCD28134648

*For research and further manufacturing use only, not for direct human use.

TFA-ap-dU|CS-0149679

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General Information

  • CAS No. 115899-40-6
  • Cat. No. CS-0149679
  • Purity ≥98%
  • MDL No. MFCD28134648
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₄F₃N₃O₆
  • Molecular Weight 377.27
  • Synonym(s) 5-TFA-ap-dU 5-TFA-ap-dU
  • SMILES O[C@H]1C[C@H](N2C(NC(C(C#CCNC(C(F)(F)F)=O)=C2)=O)=O)O[C@@H]1CO

Description

TFA-ap-dU is a synthetic nucleoside analog featuring a trifluoroacetyl-protected amino group and a 2'-deoxyribose backbone. This modified dU derivative delivers enhanced stability and compatibility in oligonucleotide synthesis workflows, enabling efficient incorporation into DNA strands under standard conditions.

Application

TFA-ap-dU serves as a versatile building block in oligonucleotide synthesis, enabling site-specific incorporation of a thymidine analog with enhanced stability and controlled reactivity. Its trifluoroacetyl-protected deoxyuridine structure facilitates efficient coupling under standard phosphoramidite protocols, offers improved solubility in organic solvents, and simplifies purification through orthogonal cleavage. Functions reliably in both solid-phase and solution-phase synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   133.65
  • LogP   -1.7927
  • H_Acceptors   7
  • H_Donors   4
  • Rotatable_Bonds   3

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