TFA-ap-dU

Name: TFA-ap-dU
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 115899-40-6
Cat. No. CS-0149679
Purity≥98%
MDL No.MFCD28134648

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HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

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Description

TFA-ap-dU is a synthetic nucleoside analog featuring a trifluoroacetyl-protected amino group and a 2'-deoxyribose backbone. This modified dU derivative delivers enhanced stability and compatibility in oligonucleotide synthesis workflows, enabling efficient incorporation into DNA strands under standard conditions.

Application

TFA-ap-dU serves as a versatile building block in oligonucleotide synthesis, enabling site-specific incorporation of a thymidine analog with enhanced stability and controlled reactivity. Its trifluoroacetyl-protected deoxyuridine structure facilitates efficient coupling under standard phosphoramidite protocols, offers improved solubility in organic solvents, and simplifies purification through orthogonal cleavage. Functions reliably in both solid-phase and solution-phase synthesis workflows.

General Information

CAS No. 115899-40-6
Cat. No. CS-0149679
Purity ≥98%
MDL No. MFCD28134648
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₁₄F₃N₃O₆
Molecular Weight 377.27
Synonym(s) 5-TFA-ap-dU 5-TFA-ap-dU
SMILES O[C@H]1C[C@H](N2C(NC(C(C#CCNC(C(F)(F)F)=O)=C2)=O)=O)O[C@@H]1CO

Computational Chemistry Data

TPSA 133.65
LogP -1.7927
H_Acceptors 7
H_Donors 4
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Alkyne

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Nucleosides & Nucleotides 5-modified Nucleoside-phosphoramidite Monomer

Life Science Click Chemistry Reagents Alkyne

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Nucleic Acid Chemistry Nucleoside Phosphoramidites

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

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TFA-ap-dU

CAS No. 115899-40-6

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