(R)-Pyrrolidine-3-carbonitrile hydrochloride

Name: (R)-Pyrrolidine-3-carbonitrile hydrochloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1153950-54-9
Cat. No. CS-0053310
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(R)-Pyrrolidine-3-carbonitrile hydrochloride|CS-0053310

Structure of 1153950-54-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1153950-54-9
Cat. No. CS-0053310
Purity ≥97%
MDL No. None
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₉ClN₂
Molecular Weight 132.59
Synonym(s) (3R)-pyrrolidine-3-carbonitrile,hydrochloride
SMILES N#C[C@@H]1CCNC1.Cl

Description

(R)-Pyrrolidine-3-carbonitrile hydrochloride is a bench-stable chiral building block featuring a stereodefined pyrrolidine core and a nitrile group. This configuration enables selective incorporation into bioactive molecules, particularly in medicinal chemistry applications requiring precise stereocontrol. The hydrochloride salt enhances solubility and handling in aqueous reaction media.

Application

(R)-Pyrrolidine-3-carbonitrile hydrochloride serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to pyrrolidine-containing scaffolds. Its well-defined stereochemistry and stable hydrochloride salt form facilitate handling, purification, and compatibility with diverse transformations. The nitrile group supports derivatization via hydrolysis, reduction, or nucleophilic addition, making it a practical component in the synthesis of bioactive heterocycles and pharmaceutical intermediates.

Synthesis

Route1
- 132945-76-7
- ~%
- In-stock
  
  1153950-54-9
References
- GLAXOSMITHKLINE LLC; HALLMAN, Jason; LAUDEMAN, Christopher; LIU, Ronggang; MILLER, Aaron; MOORE, Michael, Lee; DOCK, Steven; MUSSO, David; PARRISH, Cynthia Patent: WO2011/56635 A1, 2011 ; Location in patent: Page/Page column 50-51 ; WO 2011/056635 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301+H311+H331
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 35.82
LogP 0.54128
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

1153950-54-9 sigma1153950-54-9 manufacturer1153950-54-9 price1153950-54-9 structure1153950-54-9 SDSbuy 1153950-54-91153950-54-9 supplier1153950-54-9 uses1153950-54-9 molecular weightprice of 1153950-54-91153950-54-9 chemical name formula of 1153950-54-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

(R)-Pyrrolidine-3-carbonitrile hydrochloride

CAS No. 1153950-54-9

Recommended Products