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(R)-1,3-Dimethylpiperazine dihydrochloride

  • CAS No. 1152110-26-3

  • Cat. No. CS-0067514
  • Purity≥97%
  • MDL No.MFCD12913781

*For research and further manufacturing use only, not for direct human use.

(R)-1,3-Dimethylpiperazine dihydrochloride|CS-0067514

Structure of 1152110-26-3

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General Information

  • CAS No. 1152110-26-3
  • Cat. No. CS-0067514
  • Purity ≥97%
  • MDL No. MFCD12913781
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₆Cl₂N₂
  • Molecular Weight 187.11
  • Synonym(s) 1,3-Dimethylpiperazine dihydrochloride
  • SMILES C[C@@H]1CN(C)CCN1.[H]Cl.[H]Cl

Description

(R)-1,3-Dimethylpiperazine dihydrochloride is a bench-stable chiral amine salt featuring two methyl groups at the 1- and 3-positions of the piperazine ring. This configuration imparts enhanced stereochemical control in asymmetric synthesis, particularly in catalytic transformations and medicinal chemistry applications. The dihydrochloride form improves solubility in aqueous and polar organic media, facilitating use in reaction setups requiring precise protonation states.

Application

(R)-1,3-Dimethylpiperazine dihydrochloride serves as a chiral amine building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard coupling and functionalization reactions. Its bench-stable, crystalline form facilitates handling and purification, while the piperazine core offers favorable solubility and metabolic stability in drug candidates. Functions effectively in transition-metal-catalyzed cross-couplings and as a scaffold for diversification via alkylation or acylation.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.7535
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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