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CS-W001157 4
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(6-(Pyrrolidin-1-yl)pyridin-3-yl)boronic acid

  • CAS No. 1150114-75-2

  • Cat. No. CS-W021119
  • Purity≥96%
  • MDL No.MFCD06801704

*For research and further manufacturing use only, not for direct human use.

(6-(Pyrrolidin-1-yl)pyridin-3-yl)boronic acid|CS-W021119

Structure of 1150114-75-2

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General Information

  • CAS No. 1150114-75-2
  • Cat. No. CS-W021119
  • Purity ≥96%
  • MDL No. MFCD06801704
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃BN₂O₂
  • Molecular Weight 192.02
  • Synonym(s) 6-Pyrrolidin-1-yl-pyridine-3-boronic acid
  • SMILES OB(O)C1=CC=C(N=C1)N1CCCC1

Description

This boronate moiety integrates a pyrrolidinyl-pyridine scaffold, delivering enhanced solubility and stability in aqueous and protic solvents. The electron-rich pyrrolidine ring modulates reactivity, enabling efficient Suzuki-Miyaura coupling under mild conditions. Ideal for constructing biaryl architectures in medicinal chemistry and materials science.

Application

(6-(Pyrrolidin-1-yl)pyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The pyrrolidinylpyridyl moiety provides enhanced solubility and stability compared to simple pyridyl boronic acids, while the boronic acid group exhibits reliable reactivity with aryl halides and triflates. Its functional group tolerance and bench-stable nature facilitate straightforward purification and integration into complex molecule synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.59
  • LogP   -0.6384
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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