tert-Butyl 1,6-diazaspiro[3.4]octane-1-carboxylate

Name: tert-Butyl 1,6-diazaspiro[3.4]octane-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1148044-31-8
Cat. No. CS-0000691
Purity≥97%
MDL No.MFCD12406507

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl 1,6-diazaspiro[3.4]octane-1-carboxylate|CS-0000691

Structure of 1148044-31-8

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Description

tert-Butyl 1,6-diazaspiro[3.4]octane-1-carboxylate delivers a rigid, nitrogen-rich spirocyclic scaffold with enhanced solubility and stability. This bench-stable building block integrates seamlessly into medicinal chemistry campaigns, where its constrained geometry supports precise conformational control in target-directed ligand design.

Application

tert-Butyl 1,6-diazaspiro[3.4]octane-1-carboxylate serves as a versatile spirocyclic building block for medicinal chemistry and catalytic synthesis. The protected diamine scaffold enables selective functionalization at both nitrogen centers, with the tert-butyl carbamate group offering excellent stability and facile removal under mild acidic conditions. Its rigid, three-dimensional architecture supports efficient incorporation into complex heterocycles and bioactive scaffolds, particularly in target-oriented synthesis where conformational restraint enhances binding affinity.

General Information

CAS No. 1148044-31-8
Cat. No. CS-0000691
Purity ≥97%
MDL No. MFCD12406507
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₀N₂O₂
Molecular Weight 212.29
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1C2(CCNC2)CC1

Computational Chemistry Data

TPSA 41.57
LogP 1.3593
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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tert-Butyl 1,6-diazaspiro[3.4]octane-1-carboxylate

CAS No. 1148044-31-8

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