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Structure of 143874-13-9
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4-Ethynyl-1,2-difluorobenzene is a fluorinated aryl alkyne featuring a terminal ethynyl group ortho to two fluorine atoms. This electron-deficient scaffold enables direct coupling in transition-metal-catalyzed reactions, offering enhanced stability and compatibility in synthetic sequences requiring precise functional group placement.
4-Ethynyl-1,2-difluorobenzene serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed coupling reactions such as Sonogashira and Suzuki couplings. The ethynyl group exhibits excellent stability under standard reaction conditions, while the 1,2-difluoro substitution pattern provides enhanced metabolic stability and modulates electronic properties. This compound facilitates efficient access to fluorinated aromatic scaffolds commonly found in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS02
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H225
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Precautionary Statements : P210-P233-P240-P241-P242-P243
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Lot numbers can be found on the outside label of a product: