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CS-W001157 4
Total: USD 88.00

(1-(2-Methoxy-2-oxoethyl)-1H-pyrazol-4-yl)boronic acid

  • CAS No. 1146614-50-7

  • Cat. No. CS-0112342
  • Purity≥95%
  • MDL No.MFCD28009361

*For research and further manufacturing use only, not for direct human use.

(1-(2-Methoxy-2-oxoethyl)-1H-pyrazol-4-yl)boronic acid|CS-0112342

Structure of 1146614-50-7

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General Information

  • CAS No. 1146614-50-7
  • Cat. No. CS-0112342
  • Purity ≥95%
  • MDL No. MFCD28009361
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉BN₂O₄
  • Molecular Weight 183.96
  • Synonym(s) None
  • SMILES O=C(OC)CN1N=CC(B(O)O)=C1

Description

This pyrazolylboronic acid features a methoxy-substituted acetyl group that enhances solubility and stability under standard conditions. The boronic acid moiety enables efficient Suzuki-Miyaura coupling, while the electron-rich pyrazole ring supports selective functionalization in complex synthesis. Ideal for constructing biologically active heterocycles and advanced pharmaceutical intermediates.

Application

(1-(2-Methoxy-2-oxoethyl)-1H-pyrazol-4-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The pyrazole core provides metabolic stability and favorable solubility, while the boronic acid group exhibits excellent bench stability and compatibility with diverse functional groups. Its methoxy-ketone side chain offers additional handle for downstream derivatization, making it a practical scaffold for medicinal chemistry and process-oriented synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   84.58
  • LogP   -2.2641
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   3

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