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CS-W001157 4
Total: USD 88.00

4-Chloropyridine-3-carbaldehyde

  • CAS No. 114077-82-6

  • Cat. No. CS-0018845
  • Purity≥97%
  • MDL No.MFCD04112523

*For research and further manufacturing use only, not for direct human use.

4-Chloropyridine-3-carbaldehyde|CS-0018845

Structure of 114077-82-6

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General Information

  • CAS No. 114077-82-6
  • Cat. No. CS-0018845
  • Purity ≥97%
  • MDL No. MFCD04112523
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClNO
  • Molecular Weight 141.56
  • Synonym(s) 3-Formyl-4-chloropyridine; 4-Chloro-3-formylpyridine; 4-Chloro-3-pyridincarbaldehyde; 4-Chloronicotinaldehyde; 4-Chloropyridine-3-carboxaldehyde
  • SMILES O=CC1=C(Cl)C=CN=C1

Description

4-Chloropyridine-3-carbaldehyde features a pyridine ring bearing both chloro and aldehyde functionalities, enabling direct incorporation into heterocyclic synthesis. The electron-deficient aldehyde group facilitates nucleophilic additions, while the para-chloro substituent supports palladium-catalyzed coupling reactions. This bifunctional scaffold delivers efficient access to bioactive molecules in medicinal chemistry.

Application

4-Chloropyridine-3-carbaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic addition and coupling reactions. Its orthogonal reactivity profile—combining an electrophilic aldehyde with a halogen-bearing pyridine ring—facilitates sequential functionalization in medicinal chemistry and agrochemical development. The compound exhibits excellent bench stability and is compatible with standard purification methods, supporting scalable synthesis workflows.

Synthesis

  • Route1
    • 4-Chloropyridine|CS-0139547
      626-61-9
    • null|null
      68-12-2
    • ~84%
    • In-stock
      4-Chloropyridine-3-carbaldehyde|CS-0018845
      114077-82-6

    References

    • Takeda Chemical Industries, Ltd.; Kusaka, Masami Patent: EP1348706 A1, 2003 ; Location in patent: Page/Page column 37 ;
  • Route2
    • 4-Chloropyridine|CS-0139547
      626-61-9
    • null|null
      109-94-4
    • ~73%
    • In-stock
      4-Chloropyridine-3-carbaldehyde|CS-0018845
      114077-82-6

    References

    • Imbert, Thierry; Monse, Barbara; Koek, Wouter Patent: US2005/80085 A1, 2005 ; Location in patent: Page/Page column 8 ;
  • Route3
    • In-stock
      4-Chloropyridine hydrochloride|CS-W019791
      7379-35-3
    • null|null
      68-12-2
    • ~66%
    • In-stock
      4-Chloropyridine-3-carbaldehyde|CS-0018845
      114077-82-6

    References

    • ACHAOGEN, INC. Patent: WO2009/55696 A1, 2009 ; Location in patent: Page/Page column 87-88 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.5475
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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