Lot numbers can be found on the outside label of a product:
3',4',5'-Trimethoxyacetophenone
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CAS No. 1136-86-3
- Cat. No. CS-0075988
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 1136-86-3
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General Information
- CAS No. 1136-86-3
- Cat. No. CS-0075988
- Purity ≥98%
- MDL No. None
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₄O₄
- Molecular Weight 210.23
- Synonym(s) 3,4,5-Trimethoxyacetophenone
- SMILES O=C(C)C1=CC(OC)=C(OC)C(OC)=C1
Description
3',4',5'-Trimethoxyacetophenone features a highly electron-rich aromatic ring stabilized by three methoxy groups, enabling efficient coupling in cross-coupling reactions. The acetyl moiety provides a reactive carbonyl for nucleophilic addition or reduction. Bench-stable and moisture-tolerant, it integrates seamlessly into complex synthesis workflows.
Application
3',4',5'-Trimethoxyacetophenone serves as a versatile building block in medicinal chemistry and natural product synthesis, offering high functional group tolerance and bench stability. Its three methoxy groups enhance solubility and electron-donating character, facilitating electrophilic substitution and transition-metal-catalyzed coupling reactions. The acetyl functionality enables facile transformations including aldol condensations, reductions, and nucleophilic additions, making it a practical scaffold for constructing complex aromatic architectures.
Synthesis
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Route1
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36266-40-7 - ~91%
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In-stock
1136-86-3
References
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Zhang, Guofu; Han, Xingwang; Luan, Yuxin; Wang, Yong; Wen, Xin; Ding, Chengrong Chemical Communications, 2013 , vol. 49, # 72 p. 7908 - 7910
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Route2
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In-stock
53560-33-1 - ~75%
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In-stock
1136-86-3
References
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Bassetti, Mauro; Ciceri, Samuele; Lancia, Federico; Pasquini, Chiara Tetrahedron Letters, 2014 , vol. 55, # 9 p. 1608 - 1612
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Route3
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266329-28-6 - ~77%
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In-stock
1136-86-3
References
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Paredes; Alonso Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2292 - 2304
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 44.76
- LogP 1.915
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 4
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Key Words
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